Sanjeev Ranade
Center for Cardiovascular and Muscular Diseases
Sanford Burnham Presby
Seminar Information
Congenital heart disease (CHD) is the most common form of birth defects. Chromosomal aneuploidy (incorrect copy number) accounts for nearly 10% of CHD cases; however, the mechanisms that link incorrect chromosome copy number to malformations in heart development are poorly understood. Here, I present our recent work integrating human stem cell and mouse models of Down Syndrome to understand how increased dosage of cardiogenic genes impact heart development. As well, I present preliminary data on our lab's work using image based neural networks to extract hidden information from pluripotent stem cell models of cardiomyopathy.
Sanjeev performed his PhD studies at Scripps Research under the mentorship of Professor Ardem Patapoutian. There he uncovered the physiological roles of Piezo1 and Piezo2, two novel mechanosensitive ion channels, in vascular development and the sensory nervous system, respectively. He did his postdoctoral work on mechanisms of congenital heart disease at the Gladstone Institutes (San Francisco) with Professor Deepak Srivastava. He is currently an assistant professor at Sanford Burnham Prebys Institute in the Center for Cardiovascular and Musculoskeletal Disease.